The reports of overdose of fexofenadine are frequent, and because this, the positive effect are not established. No death occurred in tests on rats, at 5000 mg / kg, the recommended dose is 110 times the maximum a human adult. An additional research does not show any death in rats in the same concentration, which Cem equivalent to four times the recommended dose in a human being of adult. Research on humans ranges from only one dose of magnesium 800, for a dose of magnesium twice daily-690 for a month, with no adverse effect Clìnica significant when compared with placebo. To produce a part of piperidine, two phenyl groups are made using a first reaction of Grignard in ester, giving alcohol to a Tertiary. The group of alkylated amine followed with a protected aldehyde, Below the aldehyde is recovered by deprotection with acid one. The remainder of the molecule is produced by a double to iodomethane alkylation of carbanion nitrile derivatives. The group of Nitrílica hydrolysate then to the carboxylic acid. Aryl bromide is lithiated Then to produce the compound of organolithium, which can be connected to part of the aldehyde to fexofenadine (after workup).
